Hey thanks for stopping by to check out Bella’s asthma page. Thankfully her asthma seems to be under control for sometime now. Lets keep it that way! Just wanted to drop a line to redirect you to beth’s blog about Chris Jr and his, or shall I say, OUR autism. It certainly affects everyone in the house. But if you get a chance stop by and join the mailing list! http://mysensoryman.blogspot.com/
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Chris" Cause
BETA ADRENERGIC RECEPTOR BLOCKERS
BETA ADRENERGIC RECEPTOR BLOCKERS II. Beta Adrenergic Receptor Blockers A. Introduction 1. Cardiovascular effects of Beta Blockers a. Since catecholamines have positive inotropic and chronotropic effects on the heart, beta blockers slow the heart rate, and decrease myocardial contractility. When sympathetic activation is low, these drugs have modest effects. However, when sympathetic activation is high, such as during exercise and stress, beta blockers attenuate the expected increase in heart rate, and diminish cardiac output. Blockade of vascular Beta 2 receptors results in increased total peripheral resistance. Blood flow to most organs other than the brain is reduced. With long term use total peripheral resistance returns toward normal by unclear mechanisms. Beta blockers tend to decrease the capacity to work. Exercise performance is impaired less by selective Beta 1 blockers. Beta blockers have important effects on cardiac rhythm and automaticity. They reduce the sinus rate, decrease the rate of depolarization of ectopic pacemakers, and slow conduction in the atria and AV node. Lots more on this topic during lectures on antiarrhythmic drugs. Beta blockers do not lower blood pressure in normal man, however they do reduce blood pressure in hypertensive man. The mechanism of this effect has not been satisfactorily explained. Chronic prophylactic therapy with a beta blocker in patients who have had a myocardial infarct appears to help prevent the recurrence of a second fatal myocardial infarct. 2. Pulmonary effects of Beta Blockers a. Beta blockade usually has little effect on pulmonary function in normal man, however in asthmatics they can cause life threatening bronchoconstriction. Although Beta 1 selective blockers may be less likely to cause respiratory problems in asthmatics, these drugs should be used with great caution, if at all in patients with bronchospastic disease since even relatively selective blockers have some affinity for the beta 2 receptor. 3. Metabolic effects of Beta Blockers a. Catecholamines promote glycogenolysis and mobilize glucose in response to hypoglycemia. Non-selective Beta blockers adversely effect recovery from hypoglycemia in insulin dependent diabetics. Nonselective Beta blockers must therefore be used with great caution in diabetics. A selective Beta 1 blocker is usually preferable in this case. Beta blockers (Beta 3 receptor) attenuate the lipolytic response to sympathetic nervous system activation which is an important energy source for exercising muscle. Selective beta 1 antagonists may cause these effects less fequently than non-selective antagonists. B. Pharmacology of Nonselective Beta Blockers 1. Propranolol a. After oral administration, propranolol is almost completely absorbed, but undergoes extensive first pass metabolism in the liver. The extent of clearance by the liver varies radically across patients however and results in as much as a 20 fold difference in plasma concentration of the drug after oral administration to different persons. This has obvious significance in patients with liver disease. 90% of the drug in the circulation is bound to plasma proteins. When used as an antihypertensive agent, the full response on the blood pressure may not develop until after several weeks of administration. Abrupt withdrawal of propranolol after chronic therapy can lead to the develpment of withdrawal symptoms. Side effects include GI distress (relatively unopposed parasympathetic nervous system), and CNS effects such as nightmares, insomnia, and depression. 2. Nadolol a. Nadolol is a nonselective beta blocker with a long duration of action. Nadolol is poorly lipid soluble, and incompletely absorbed from the GI tract. Interindividual variability in its bioavailability is less than with propranolol. It is not extensively metabolized, and is excreted intact in the urine. As such kidney disease is a cause for concern, and may result in an accumulation of nadolol. Because nadolol is poorly lipid soluble, it is thought that there will be lower concentrations of nadolol in the brain, and this may contribute to a lower incidence of CNS side effects seen with this drug. 3. Timolol a. It is a nonselective blocker with a short duration of action. It is well absorbed from the gut and is subject to moderate first pass metabolism. It is metabolized by the liver and only a small fraction is excreted by the kidney in unchanged form. Timolol is an example of a beta blocker which is used in glaucoma to reduce the rate of synthesis of aqueous humor. The ocular form of timolol is well absorbed into the circulation and adverse effects can occur in patients with asthma or congestive heart failure. b. Other new drugs with similar mechanisms of action include Bopindol, Carteolol, oxprenolol, penbutolol, sotalol etc etc 4. Labetolol a. It is an example of a nonselective beta blocker which also blocks alpha 1 receptors. It also inhibits uptake of NE from the synaptic cleft (a cocaine-like effect). Its pharmacokinetics are like those of Propranolol discussed above, ie well absorbed, highly metabolized and very variably so on first pass through liver, mainly metabolized by liver. It is used in the treatment of pheochromocytoma and hypertensive emergency, where its alpha 1 effects promote vasodilation and hypotension, while its beta 1 effect helps reduce reflex tachycardia. b. Other new drugs with a similar mechanism of action include Carvedilol, Medroxalol, Bucindolol C. Pharmacology of Selective Beta Blockers 1. Metaprolol a. It is a selective Beta 1 antagonist, whose pharmacokinetics are like propranolol. 2. Atenolol a. It is also a selective Beta 1 antagonist. It is a poorly lipid soluble drug. About half of an oral dose is absorbed, but most of this reaches the systemic circulation ie there is no first pass metabolism in the liver. As a result, peak concentrations of this drug in the plasma are not so variable across patients. It is excreted unchanged in the urine. It has a somewhat longer duration of action than metaprolol. 3. Esmolol a. it is a selective Beta 1 antagonist with a very very short duration of action. It is given by iv infusion. It has a half life of about 8 minutes in plasma, and is metabolized by plasma esterases. It is used only for the treatment of atrial tachycardia. b. Other new drugs with a similar mechanism of action include Bisoprolol, Nebivolol, Betaxolol D. Toxic Effects of Beta Blockers 1. Patients with impaired cardiac function have high levels of sympathetic activation of the heart to provide support for cardiac performance. In these patients, beta blockers may provoke an acute incident of congestive heart failure. In fact use of beta blockers in heart failure was once contraindicated. a. Despite this fact, beta antagonists are currently being used for the treatment of mild to moderate degrees of congestive heart failure. Not all beta blockers are equally efficacious, however metoprolol appears to be useful. The mechanisms which underly this beneficial effect are poorly understood at this time. 2. Arrhythmias, especially bradyarrhythmias . 3. Bronchoconstriction, especially in asthmatics 4. CNS effects include sleep disturbances & depression 5. Metabolic effects include delayed recovery from insulin induced hypoglycemia. E. Drug Interactions 1. Drugs that induce hepatic drug metabolizing enzymes will reduce the plasma concentrations of beta blockers that are extensively metabolized by the liver. These include barbiturates, many miscellaneous sedative hypnotic drugs, phenytoin (diphenylhydantoin), as well as smoking. F. Therapeutic Uses of Beta Blockers 1. Used as Antihypertensives especially in mild cases where they are less likely than other agents to provoke postural hypotension. 2. In the treatment of ischemic heart disease a. In angina, beta blockers reduce cardiac work and oxygen consumption. This reduces the frequency of anginal episodes. b. Long term prophylactic use of nonspecific beta blockers helps prevents the recurrence of a fatal second myocardial infarct in patients who survived an initial attack. The mechanism of this effect is not known. 3. In the treatment of mild to moderate degees of congestive heart failure, chronic treatment with certain beta-1 blockers prolong the life expectancy. 4. Beta blockers are antiarrhythmics. More in other lectures. Here, only mentioned their ability to block atrial tachycardia. 5. In glaucoma, beta blockers decrease the rate of synthesis of aqueous humors. 6. Many of the signs and symptoms of hyperthyroidism are due to sympathetic nervous system activation. Beta blockers reduce these symptoms. 7. Beta blockers are useful in the prophylaxis of migraine, but not in treatment.
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Chronic Asthma Home Remedies (cough variant asthma)
cough variant asthma
Recurring health barriers are certainly annoying to deal with. Illnesses such as cancer, asthma, diarrhea and stress deliver different degrees of symptoms and consequences. In the case of asthma, breathing is usually distorted at any unexpected time. This certain health liability can kick off at any age but it usually sets at childhood stage. It is even deemed to be the most popular chronic disease among kids, with about 15 t0 20% of the children populace getting affected. Chronic asthma home remedies can be executed to avoid undesirable attacks.
Before learning some chronic asthma home remedies, it’s appropriate to learn the rudiments of the disease, its causes and symptoms. When airways are inflamed and narrowed down, breathing becomes hard and that’s when asthma attacks. It later leads to wheezing wherein the air coming from the nose is breathed out through lessened tubes. Varied factors are considered to have caused asthma attacks like family history, immune system troubles, exposure to cigarette smoke, allergies, infections, reactions to selected foods, bodily reactions to stress and emotional trauma. Asthma could kill one if not remedied immediately.
It’s said that wheezing worsens at the maximum level when it’s dawn. When a person’s airways are limited, no ample oxygen is able to enter and get circulated through the bloodstream. That’s why a person can transform into bluish color when attacked by asthma. A severe cause to this can be very alarming and threatening, and what’s the worst part is that it could stop your heartbeat. There are many kinds of asthma, as told by medical professionals. They include adult asthma, infant asthma, childhood asthma, cough variant asthma, cardiac asthma, coughing asthma, bronchial asthma and chronic asthma. Because the basic problem with asthma as contributed by the difficulty of air to come in and out of the lungs, the quickest remedy to apply is through using the medical inhalers. The so-called bronchodilators can expand the airways. Chronic asthma home remedies are also beneficial to be administered to those experiencing asthma repeatedly for a longer time.
One of the popular chronic asthma home remedies can is done by using a nebulizer that gives in a much larger dose of asthma-intended drugs. The drugs in the nebulizer go immediately to the lungs so that’s why response can be as quick as possible. Breathing exercises can be helpful to improve the breathing mechanism of the person. Cardiovascular exercises like swimming, jogging, kickboxing, step aerobics and skipping can also provide long-term benefits to the way a person breathes. Eventually, he will be able to lessen the occurrence of asthma attacks. Also, you can get the habit of drinking herbal versions of milk and tea or perhaps eat some soup taken from drumstick leaves, pear-shaped fruits called figs, and ginkgo biloba. These have all been proven and tested to reduce the frequency of asthma occurrences.
Ian Pennington is an accomplished niche website developer and author. To learn more aboutasthma remedies, please visit At Home Asthma Care for current articles and discussions. Article Source: http://EzineArticles.com/?expert=Ian_Pennington |
Clean pacifier by sucking away children from asthma
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| Illustration pacifiers. © Shutterstock.com / Ilya Andriyanov |
Cleaning pacifier sucking ways might be considered dirty. Most parents will clean pacifier by washing with tap water. But the researchers found that older people who clean pacifier to suck can keep children from the risk of asthma and hives. This study does not prove that the technique may protect children from asthma or allergies. However, researchers believe that the possibility of transfer of oral bacteria and microbes of parents in children can boost the immune system and the digestive system which in turn makes the child they are exposed to a small risk of allergy or asthma. “We know that bacteria are also important for growing children,” said Dr. Wilfried Karmaus from the University of Memphis, as reported by Reuters. In this research, scientists recruited pregnant women in one of the Swedish hospitals and followed them for three years. Of the 184 infants who were observed, 80 percent have parents with allergies. After the babies were tested at the age of 18 and 36 months. In the first test 46 infants have eczema and 10 had symptoms of asthma. Children who use the usual dot cleaned by his mother smoked by 63 percent less likely to have eczema and 88 percent less affected by asthma. While in the second test, when the baby was 36 months, the difference for asthma began to disappear, while babies with pacifiers are cleaned by his mother smoked still have a 49 percent lower risk of developing eczema. Researchers believe that more research must be done to demonstrate clearly the benefits of cleaning with megisapnya dot. Before clear, researchers would not recommend this technique for the parents.
I am now halfway through radiation :-)
    I am so very happy that I have now made it halfway through radiation but it does come with alot of other concerns right now. The side effects are starting to take place now and I can tell that I will be starting to lose my hair very shortly. It comes out a little now with just a little tug but my head is just so sensitive and when I touch my hair it just seems to hurt to the roots. I am also still having the wonderful headaches. They did start me up on the steroids to help with the swelling and to take the headaches away but the steroids make me feel so much worse phyically. I have been trying to figure out over the last week how little of these I could take and still feel somewhat normal without the headaches but not a lot of luck with this so far. Tomorrow I will just have to suck it up and take the steroids like I was told… who ever said these Dr’s knew best? My body just kind of aches now and I look forward to the end of this radiation but I do know that I have some other things going on that has me very concerned.
  When I was told 2 weeks ago that we would be doing whole brain radiation they told me that they didn’t want me to be taking my chemo pills as this would make my radiation side effects so much worse. I spoke with my oncologist about this and he agreed that I needed to stop taking them while I was going through this treatment. So I have not been taking these pills for the past 2 and a half weeks. I have now started to have the cough come back and my lungs feel very heavy again. I have a hard time breathing and really it feels like I am having an asthma attack. I decided that it was best if I called my Dr today as it really scares me to think that I have only been off of these pills a short while and could the cancer start growing this quickly? When I talked to him he said that more then likely if it had started to grow again that it was doing it while I was still taking the pills and not just in a 2 week period. So tomorrow I go in for a lung x-ray to find out if there is any change. I already know the answer to this question and am just trying to prepare myself for what will be said. I would so LOVE for my body to work with me a little bit here but I also know that not everything is always in my hands. I need to just keep my faith and know that everything will end up working out just how it should. Besides I also have LOTS of fight left in ME!
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Allergies & Asthma
Allergies are often treated with chiropractic care. Many allergic and asthmatic reactions are caused by hypersensitivity of the immune system and/or respiratory system. Researchers have found that the immune and respiratory systems depend on normal communication from the brain and spinal cord to control and coordinate their functions properly.
Therefore, if your neck is misaligned, it could cause an imbalance in your nervous system function. This upper cervical spinal joint irritation could possibly produce or exaggerate asthmatic and allergic symptoms. For example; many asthma and allergy sufferers experienced traumas such as head injuries, auto accidents, or falls which could have injured their upper cervical spines. The good news is that we can perform an upper cervical examination to determine if chiropractic care can reduce your allergic and asthmatic reactions.
Schedule an appointment today!
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